Hypertensive Agents Penicillins can cause … The exact cause-and-effect relationship is unknown, but may be associated with a decreased aqueous component of the precorneal tear film.9. Proton pump inhibitors have caused dry eye complaints, although this information does not appear in their individual package inserts. This can lead to dry eyes in rheumatoid arthritis, lupus and Sjogren’s syndrome. Antihistamines are combined with anticholinergics in many OTC medications, such as cold preparations, sedatives, antidiarrheals and nasal decongestants.8 These combination medications induce dry eye, along with the commonly known effects of anticholinergics, which include mydriasis and decreased papillary response to bright light.8, Hormones 2007;67(1):75-93. They point out that the more medications a person is taking, the greater the likelihood that a combination could contribute to dry eyes. Antidepressants, Psychosis, and … In 2006, Long Island University awarded him an honorary doctorate as “one of the country's leading drug experts for the consumer.”, Eye drop preservative (benzalkonium chloride). 17. Jaanus SD. Medications that block histamine receptors alleviate allergic conditions of rhinitis, uticaria, dermatitis and systemic allergies. There are several medications which have the potential to worsen the symptoms of Dry Eye. Bowling is in private group practice in Tuscaloosa, Ala. Antidepressant & Parkinson’s Medications Any prescription medication with a nerve-inhibiting quality has the potential to cause dry eye symptoms. Antibiotics taken orally have been known to cause dry eyes. Muchnick BG. Medications that can cause this include Adipex (for obesity), Celebrex (inflammation), Lamictal (seizures), Mevacor (elevated cholesterol), Tylenol (pain relief) and Zantac (ulcers). Santaella RM, Fraunfelder FW. Dr. 2001 Sep;132(3):299-305. Recommend your patients use only one pharmacy so the pharmacist can help monitor for drug interactions. As always, the best course is to educate our patients about the role their medications play in their dry eye complaints. Such a drip-by-drip solution is unlikely to alleviate the problem. Xiidra® (lifitegrast ophthalmic solution 5%) became FDA … This incredibly unpleasant condition can be caused by a number of things. Drug Saf. 2006;5(5):467-8. Acupuncture. Bartlett JD. The drugs in this class reduce mucous and aqueous production, which cause dry eye complaints.7 Their activity may also decrease the aqueous component of the precorneal tear film. 15. Castor oil eyedrops. Some of these procedures … Chemotherapy Medications 5. Mellaril (thioridazine, Mutual Pharmaceutical) is the best known of this class and has almost completely replaced Thorazine (chlorpromazine, GlaxoSmithKline) in the management of the condition. Optom Mgmt. Some people begin to experience dry eye after laser vision correction surgery. Thiazides or diuretics are often prescribed to treat congestive heart failure. A review article in the Journal of Ophthalmology (online, Aug. 27, 2012) lists many such drugs … While these drug categories are the most common offenders in producing dry eye problems, exceptions exist in every drug category. National Academies Press, July 20, 2006. Common Medication Examples. If you have found a solution, please share your success story with others. Certain classes of drugs are known to cause eye problems. Skin Medications Medications … Gastrointestinal Medications Lemp MA, Baudouin C, Baum J, et al. Joe Graedon is a pharmacologist who has dedicated his career to making drug information understandable to consumers. Hormone replacement therapy and dry eye syndrome. Ophthalmic toxicity by systemic drugs. Dry Eye Culprits of the Drug World. A major drug in this class is Cytoxan (cyclophosphamide, Bristol-Myers Squibb), which is also used to treat ocular cicatricial pemphigoid and primary Sjögren syndrome. Debra A. Schaumberg, Sc.D., O.D., M.P.H., and colleagues reported a 69% increase in dry eye symptoms in women who were taking estrogen compared to the control group.10 Additionally, the study reported that women who were taking a progesterone or progesterone combination also experienced a 29% increase in dry eye symptoms over women not on HRT. If a medication contributed to your symptoms, we would like to learn about that as well. 2nd ed. Encephale. “Many doctors think erectile dysfunction drugs cause … Optom Mgmt. Birth control pills. Symptoms of blurred vision, cycloplegia and dry eye are transient and reversible.7. 14. 2008 Jan;145(1):60-73. Hormone replacement therapy (HRT) with estrogens alone or in combination with progestins is a commonly prescribed therapy for post-menopausal women. Physicians and pharmacists rarely mention dry eyes as a drug side effect. 19. That is why diabetes, herpes eye infection and laser eye surgery (LASIK) may sometimes result in dry eyes. Jasper A. Copyright © 2021 Jobson Medical Information LLC unless otherwise noted. Antidepressants Antidepressants and anti-anxiety medications also can produce dry eye symptoms. If eye drops and medication don’t work, procedures may be used to treat dry eyes. Jaanus SD, Bartlett JD, Hiett, JA. Treatment will be different for each person depending on the root cause of the dry eye. Dry eye is often a side effect of certain medications. 2001;27(6):588-99. 2. Pharmaceuticals that can cause dry eye symptoms include certain medications used to treat hypertension such as central-acting agents and diuretics; antihistamines and decongestants, in concert with anticholinergics; hormones; certain antidepressants; pain relievers, such as ibuprofen and lortab; and dermatologic agents. Here are the broad categories and specific medications that have been known to potentially … 2009 Nov;24-58. In: Bartlett JD & Jaanus SD (eds.). Two well-known antidepressants are Zoloft (sertraline, Pfizer) and Paxil (paroxetine, GlaxoSmithKline). Schaumberg DA, Buring JE, Sullivan DA, et al. Laser surgery. Even though Roche Pharmaceuticals pulled Accutane from the market in 2009, generic versions of the drug may still be available by prescription. Further study is needed, but some alternative medicine approaches may help relieve your dry eye symptoms. Adding omega-3 fatty acids to your diet may help relieve dry eye signs and symptoms. Ophthalmic Toxicology. The effect of treatment and its related side effects in patients with severe ocular cicatricial pemphigoid. 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